Curriculum Vitae Dr. Arquimedes Cheffer
LinkedIn: https://www.linkedin.com/in/drarquimedescheffer/
Google Scholar: https://scholar.google.com/citations?user=HILT6GoAAAAJ&hl=en
Personal Data
Title: Dr.
First name: Arquimedes
Name: Cheffer
Current position: Postdoctoral researcher
Identifiers/ORCID 0000-0002-5973-6333
Qualifications and Career
Degree programme
2006-2008, Molecular Biology and Biochemistry MSc., Institute of Chemistry, University of Sao Paulo
2002-2005, Pharmacy BSc., Federal University of Juiz de Fora
Doctorate
2008-2013, Molecular Biology and Biochemistry, Institute of Chemistry, University of Sao Paulo
Further stages
2021-present, Institute of Anatomy and Cell Biology, University of Freiburg
2019-2021, Institute of Reconstructive Neurobiology – University of Bonn
2017-2018, Max Planck Institute for Biophysical Chemistry
2013-2018, Institute of Chemistry, University of Sao Paulo
Engagement in the Research System
In addition to my research in Neuroscience, I have also given Molecular Biology, Biochemistry and Neuroanatomy courses to undergraduate students, as well as trained many master and PhD students.
Scientific Results
Izzo A*, Akol I, Villarreal A, Lebel S, Garcia-Miralles M, Cheffer A, Bovio P, Heidrich S, Vogel T* (2023). Nucleophosmin 1 cooperates with the methyltransferase DOT1L to preserve peri-nucleolar heterochromatin organization by regulating H3K27me3 levels and DNA repeats expression. Epigenetics Chromatin. 28;16(1):36. doi: 10.1186/s13072-023-00511-9. *shared correspondance
Cheffer A, Garcia-Miralles M, Maier E, Akol I, Franz H, Srinivasan VSV, Vogel T (2023) DOT1L deletion impairs the development of cortical parvalbumin-expressing interneurons. Cereb Cortex. 11:bhad281. doi: 10.1093/cercor/bhad281.
Appiah B, Fullio CL, Ossola C, Bertani I, Restelli E, Cheffer A, Polenghi M, Haffner C, Garcia-Miralles M, Zeis P, Treppner M, Bovio P, Schlichtholz L, Mas-Sanchez A, Zografidou L, Winter J, Binder H, Grün D, Kalebic N, Taverna E, Vogel T (2023) DOT1L activity affects neural stem cell division mode and reduces differentiation and ASNS expression. EMBO Rep. 29:e56233. doi: 10.15252/embr.202256233.
Cheffer A, Flitsch LJ, Krutenko T, Röderer P, Sokhranyaeva L, Iefremova V, Hajo M, Peitz M, Schwarz MK, Brüstle O (2020) Human stem cell-based models for studying autism spectrum disorder-related neuronal dysfunction. Mol Aut 11(1):99. doi: 10.1186/s13229-020-00383-w
Rajpurohit CS, Kumar V, Cheffer A, Oliveira D, Ulrich H, Okamoto OK, Zatz M, Ansari UA, Khanna VK, Pant AB (2020) Mechanistic Insights of Astrocyte-Mediated Hyperactive Autophagy and Loss of Motor Neuron Function in SOD1L39R Linked Amyotrophic Lateral Sclerosis. Mol Neurobiol 57:4117-4133. doi: 10.1007/s12035-020-02006-0
Viviani LG, Piccirillo E, Cheffer A, de Rezende L, Ulrich H, Carmona-Ribeiro AM, do Amaral AT (2018) Be aware of aggregators in the search for potential human ecto-5'-Nucleotidase inhibitors. Molecules 23:1876. doi: 10.3390/molecules2308187
Gonçalves MCB, Corrêa-Velloso J, Naaldijk Y, Cheffer A, Ulrich H (2018) Purinergic modulation of pathways associated to suicidal behavior. Mol Psychiatry 25:514-516. doi: 10.1038/s41380-018-0088-3
Cheffer A, Castillo ARG, Corrêa-Velloso ,; Gonçalves MCB, Naaldijk Y, Nascimento IC, Burnstock G, Ulrich H (2018) Purinergic system in psychiatric diseases. Mol Psychiatry 23:94-106. doi: 10.1038/mp.2017.188
Pillat MM, Cheffer A, Andrade CM, Morsch VM, Schetinger MRC, Ulrich H. (2015) Bradykinin-induced inhibition of proliferation rate during neurosphere differentiation: consequence or cause of neuronal enrichment? Cytometry Part A, v. 87, p. 929-935. doi: 10.1002/cyto.a.22705.
Cheffer A, Mustafa EV, Amaral AT -do, Ulrich H. (2012) Lipophilicity as a determinant of binding of procaine analogs to rat α3β4 nicotinic acetylcholine receptor. J Neurosci Res v. 90, p. 1607-1614. doi: 10.1002/jnr.23047
Cheffer A, Ulrich H. (2011) Mechanism of the rat alpha3beta 4 nicotinic acetylcholine receptor by the Alzheimer therapeutic tacrine. Biochemistry, v. 50, p. 1763-1770. doi: 10.1021/bi101789y